Last update June 14, 2023

Osimertinib

Incompatible

Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Commentary.

It is an antineoplastic, tyrosine kinase inhibitor, used in the treatment of certain types of lung cancer.. Oral administration once daily.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic characteristics (very high plasma protein binding, very large volume of distribution and moderately elevated molecular weight) make it very unlikely its excretion into breast milk in significant amounts.

Its long half-life could facilitate excretion in breast milk and due to its high bioavailability, it would have systemic action in the infant.

It has potentially very serious side effects.

It is known from pharmacokinetics that after 3 elimination half-lives (T½) 87.5% of the drug is eliminated from the body; after 4 T½ it is 94%, after 5 T½, 96.9%, after 6 T½, 98.4% and after 7 T½ it is 99%. From 7 T½ the plasma concentrations of the drug in the body are negligible. In general, a period of at least five half-lives can be considered a safe waiting period before breastfeeding again.(Anderson 2016).

Taking the longest T½ published as a reference (48 hours), these 5 T½ would correspond to 10 days. Meanwhile, breast milk must be expressed and discarded regularly. This does not allow breastfeeding during treatment.


See below the information of this related product:

  • Maternal Cancer; Maternal Neoplasia (Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.)

Alternatives

We do not have alternatives for Osimertinib.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Osimertinib is also known as


Osimertinib in other languages or writings:

Groups

Osimertinib belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Osimertinib in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 70 %
Molecular weight 500 daltons
Protein Binding 95 %
VD 13.11 l/Kg
pKa 13.64 -
Tmax 6 hours
48 hours

References

  1. Astra Zeneca. Osimertinib. Drug Summary. 2023 Full text (in our servers)
  2. EMA. Osimertinib. Ficha técnica. 2022 Full text (in our servers)

Total visits

760

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by La Liga de la Leche, España of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM