Last update Dec. 28, 2023

Niflumic Acid

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Niflumic acid is a cyclooxygenase-2 inhibitor, derived from nicotinic acid and the main metabolite of morniflumate. It has non-steroidal anti-inflammatory properties (NSAID), used to relieve inflammation, pain and edema in acute and chronic inflammatory conditions (rheumatoid arthritis, osteoarthritis and post-operative and post-traumatic events). Oral administration 3 to 4 times daily and typically as an ointment. Morniflumate is the morpholinoethyl ester of niflumic acid, with similar properties.

According to manufacturer's data, its excretion in breast milk is minimal, being the concentration reached in milk one hundredth of the plasma concentration. (AEMPS 2023)

Its high percentage of binding to plasma proteins makes it unlikely that significant amounts will pass into milk. 

Given the scarcity of published data on this drug and breastfeeding, it may be safer to use anti-inflammatory drugs of proven safety in breastfeeding.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Niflumic Acid is also known as


Niflumic Acid in other languages or writings:

Groups

Niflumic Acid belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Niflumic Acid in its composition:

List of 9 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 283 / 395 daltons
Protein Binding 90 %
VD 0.12 l/Kg
Tmax 2 hours
T½ 2 - 2.5 hours
M/P ratio 0.01 -

References

  1. AEMPS. Ácido niflúmico. Ficha técnica 2023 Full text (in our servers)
  2. Alessandri JL, Abossolo T, Reynaud I, Montbrun A, Sommer JC, Tilmont P. [Non-steroidal anti-inflammatory agents and pregnancy. A study of renal and digestive toxicity of niflumic acid in the perinatal period]. J Gynecol Obstet Biol Reprod (Paris). 1994 Abstract
  3. Chevallier B, Baudet V, Doumaz Y, Renaud C, Costil J. [Neonatal renal insufficiency secondary to niflumic acid administration in pregnancy]. Arch Fr Pediatr. 1992 Abstract
  4. Houin G, Tremblay D, Bree F, Dufour A, Ledudal P, Tillement JP. The pharmacokinetics and availability of niflumic acid in humans. Int J Clin Pharmacol Ther Toxicol. 1983 Abstract

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