Last update March 2, 2024

Netilmicin Sulfate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Netilmicin is a semi-synthetic aminoglycoside antibacterial with actions and uses similar to those of gentamicin. Parenteral administration and in the form of eye drops.

At the time of the last update, we found no published data on its excretion in breast milk.

Aminoglycosides have a polar structure, resulting in negligible penetration through biological membranes and minimal oral absorption. (Arbex 2010, Chin 2001)

Its very low oral bioavailability makes it difficult to pass into infant plasma from ingested breast milk, except in premature infants and immediate neonatal period in which there may be greater intestinal permeability.

Ophthalmic use is completely compatible with lactation.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Netilmicin Sulfate in other languages or writings:

Group

Netilmicin Sulfate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Netilmicin Sulfate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 1.442 daltons
Protein Binding 10 %
VD 0.1 l/Kg
pKa 12.55 -
Tmax 0.5 - 1 hours
2.5 hours

References

  1. Arbex MA, Varella Mde C, Siqueira HR, Mello FA. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs. J Bras Pneumol. 2010 Abstract Full text (link to original source) Full text (in our servers)
  2. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract
  3. Chung M, Costello R, Symchowicz S. Comparison of netilmicin and gentamicin pharmacokinetics in humans. Antimicrob Agents Chemother. 1980 Feb;17(2):184-7. Abstract Full text (link to original source)

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