Last update Nov. 5, 2024

Nedocromil Sodium

Compatible

Safe product and/or breastfeeding is the best option.

Nedocromil sodium is a pyranoquinoline with stabilizing action on mast cells similar to that of cromoglycate sodium. It is administered by inhalation for the prevention of asthma and atopic rhinitis and in the form of eye drops for allergic conjunctivitis. 

At the time of the last update, we found no published data on its excretion in breast milk. 

Its pharmacokinetic data (very low inhaled, oral and ophthalmic bioavailability with very low plasma levels, moderately high molecular weight and high percentage of protein binding) make it very unlikely that significant amounts will pass into milk, which would also be poorly absorbed by the infant. 

It is a well-tolerated drug and has practically no side effects, none of them serious. 

The small dose and the low plasma absorption of most inhaled (buccal or nasal), ophthalmologic or topical dermatologic preparations make the passage of significant amounts into breast milk unlikely.

 

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Nedocromil Sodium in other languages or writings:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. oral 3. Inhal10 %
Molecular weight 415 daltons
Protein Binding 89 %
pKa 2.2 -
Tmax 0.5 hours
1 - 3.3 hours

References

  1. AEMPS. Nedocromil. Ficha técnica. 2012 Full text (in our servers)
  2. Sanofi. Nedocromil. Drug Summary. 2008 Full text (in our servers)
  3. Nice FJ, De Eugenio D, Dimino TA, Freeny IC, Rovnack MB, Gromelski JS. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and Other Healthcare Professionals. Part I. J Pharm Technol 2004;20:17-27. doi: 10.1177/875512250402000106.
  4. Neale MG, Brown K, Foulds RA, Lal S, Morris DA, Thomas D. The pharmacokinetics of nedocromil sodium, a new drug for the treatment of reversible obstructive airways disease, in human volunteers and patients with reversible obstructive airways disease. Br J Clin Pharmacol. 1987 Abstract

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