Last update Jan. 24, 2017

Натрия Пентозана Полисульфат


Safe substance and/or breastfeeding is the best option.

Sulfated polysaccharide of plant origin with anticoagulant and fibrinolytic properties similar to heparin. Topical, oral and parenteral administration (subcutaneous, intramuscular or intravenous).
Orally used for pain relief of the urinary tract on interstitial cystitis.
Topically used on superficial venous disorders, hemorrhoids and hematomas.

At latest update relevant published data on its excretion into breast milk were not found.

Because of a high molecular weight, excretion into breastmilk in significant amounts seems very unlikely.
A low or not at all oral bioavailability (Faaij 1999, Simon 2005) makes it seems difficult the pass into the infant’s plasma through the breast milk ingested, except for premature infants and immediate neonatal period, in which there may be an increased intestinal permeability.

Do not apply it on the chest to prevent the infant from ingesting it; if necessary, do it after a feeding and clean it up thoroughly with water before the next one.


We do not have alternatives for Натрия Пентозана Полисульфат since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Натрия Пентозана Полисульфат is Pentosan Polysulfate Sodium in Cyrillic.

Is written in other languages:

Натрия Пентозана Полисульфат is also known as


Натрия Пентозана Полисульфат belongs to this group or family:


Main tradenames from several countries containing Натрия Пентозана Полисульфат in its composition:


Variable Value Unit
Oral Bioavail. 0 - 6 %
Molecular weight 4.000 - 6.000 daltons
Tmax 3 hours
20 hours


  1. IARC - WHO. International Agency for research on Cancer. Some Drugs and Herbal Products. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 108. 2016 Full text (link to original source)
  2. AEMPS. Pentosano. Ficha técnica. 2007 Full text (in our servers)
  3. Simon M, McClanahan RH, Shah JF, Repko T, Modi NB. Metabolism of [3H]pentosan polysulfate sodium (PPS) in healthy human volunteers. Xenobiotica. 2005 Abstract
  4. FDA. Pentosan. Prescribing Information. 2002 Full text (in our servers)
  5. Faaij RA, Srivastava N, van Griensven JM, Schoemaker RC, Kluft C, Burggraaf J, Cohen AF. The oral bioavailability of pentosan polysulphate sodium in healthy volunteers. Eur J Clin Pharmacol. 1999 Abstract
  6. Peters M, Witvrouw M, De Clercq E, Ruf B. Pharmacokinetics of intravenous pentosan polysulphate (HOE/BAY 946) in HIV-positive patients. AIDS. 1991 Abstract
  7. Dawes J, Prowse CV, Pepper DS. Absorption of heparin, LMW heparin and SP54 after subcutaneous injection, assessed by competitive binding assay. Thromb Res. 1986 Abstract

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