Last update May 24, 2025

Натрий Цефоницид

Compatible

Safe product and/or breastfeeding is the best option.

Second-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available (Rowe 2013, Fulton 1992), excretion occurs in breast milk in very small amount and it is clinically insignificant. (Lou 1984)

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal microbiome in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Alternatives

We do not have alternatives for Натрий Цефоницид since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Натрий Цефоницид is Cefonicid Sodium in Cyrillic.

Is written in other languages:

Group

Натрий Цефоницид belongs to this group or family:

Tradenames

Main tradenames from several countries containing Натрий Цефоницид in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 587 daltons
Protein Binding 98 %
Tmax 1.25 hours
T½ 4.5 hours
M/P ratio 0.0024 -
Theoretical Dose 0.045 mg/Kg/d
Relative Dose 0.27 %

References

  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  3. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  4. Lou MA, Wu YH, Jacob LS, Pitkin DH. Penetration of cefonicid into human breast milk and various body fluids and tissues. Rev Infect Dis. 1984 Abstract

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