Last update Jan. 13, 2024

Nabumetone

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Nabumetone is a prodrug that is metabolized to an NSAID, 6-methoxy-2-naphthylacetic acid (6-MNA), structurally similar to naproxen. It is used to treat osteoarthritis and rheumatoid arthritis. Oral administration once daily.

At the time of last review, there are no published data regarding breastfeeding. 

Its high percentage of fixation to plasma proteins makes its passage into milk very unlikely. 

Its low oral bioavailability protects the infant from absorption. 

Until more data are available on this drug in relation to breastfeeding, other safe and well-documented alternatives are preferable.


See below the information of this related product:

Alternatives

  • Diclofenac ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ibuprofen ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ketorolac Trometamol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Paracetamol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Piroxicam ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Nabumetone in other languages or writings:

Tradenames

Main tradenames from several countries containing Nabumetone in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 35 %
Molecular weight 228 daltons
Protein Binding 99 %
VD 0.1 - 0.2 l/Kg
pKa 19.59 -
Tmax 9 - 12 hours
24 (19 - 36) hours

References

  1. PDR Nabumetone Drug Summary 2013 Full text (in our servers)
  2. Nabumetona Ficha técnica 2007 Full text (in our servers)

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