Last update Sept. 9, 2022

Na2HPO; NaH2PO4,xH2O ; Na3PO4


Safe substance and/or breastfeeding is the best option.

Phosphates are used as a laxative and to clean the bowel before medical examinations. They base their action on the little or zero amount which is absorbed (Nice 2000), causing water to escape from the intestine and severe diarrhea.

Since the last update, we have not found published data on its excretion in breast milk.

Both sodium and phosphate are normal components of the body and are found in breast milk at concentrations different to plasma. (Allen 1991)

Temporary increases in plasma phosphate levels have been observed after the administration of sodium phosphate enema (Salix 2009, Ehrenpreis 2009). It is not known whether this may affect the concentration of phosphate in breast milk, but it is believed that the variation is minimal, temporary and does not have clinical repercussions in the infant.

Take into account the loss of liquids to drink as much as needed and avoid dehydration of the nursing mother who is already producing about 1 litre of liquid in the form of milk a day.

Expert authors consider phosphate-based laxatives compatible with breastfeeding. (Nice 2000)

A nursing mother reported to us in 2022 that her 16-month-old infant had two profuse but self-limiting liquid stools in the 24 hours after she had taken a dibasic/monobasic phosphate preparation as a preoperative preparation.


We do not have alternatives for Na2HPO; NaH2PO4,xH2O ; Na3PO4 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Main tradenames from several countries containing Na2HPO; NaH2PO4,xH2O ; Na3PO4 in its composition:


Variable Value Unit
Oral Bioavail. < 20 %
Molecular weight 120 / 142 /164 daltons
pKa 1.8 -
Tmax 1 - 3 hours


  1. Ehrenpreis ED. Increased serum phosphate levels and calcium fluxes are seen in smaller individuals after a single dose of sodium phosphate colon cleansing solution: a pharmacokinetic analysis. Aliment Pharmacol Ther. 2009 Abstract
  2. Salix. Sodium phosphate mono & dibasic (Visicol). Drug Summary. 2009 Full text (in our servers)
  3. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  4. Allen JC, Keller RP, Archer P, Neville MC. Studies in human lactation: milk composition and daily secretion rates of macronutrients in the first year of lactation. Am J Clin Nutr. 1991 Abstract

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