Last update Aug. 16, 2022
Very Low Risk
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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N02AF02 is Nalbuphine Hydrochloride in ATC Code/s.Is written in other languages:
N02AF02 belongs to this group or family:
Main tradenames from several countries containing N02AF02 in its composition:
|Oral Bioavail.||11.8 (6 – 20)||%|
|Tmax||0.01 - 0.25||hours|
|T½||2.4 - 5||hours|
|Theoretical Dose||0.007 – 0.009||mg/Kg/d|
|Relative Dose||0.59 ± 0.27||%|
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
A strong opioid analgesic equivalent to morphine with a partially antagonistic action. It is used during childbirth and cesarean section. Administered subcutaneously, intramuscularly or intravenously every 3 to 6 hours.
It is excreted in breastmilk in clinically insignificant amounts. (Reece 2017, Mustafa 2016, FDA 2016, Jacqz-Aigrain 2007, Wischnik 1988)
Its low oral bioavailability (Aitkenhead 1988) hinders transfer to the infant’s plasma from ingested breastmilk.
The time of onset of breastfeeding was delayed in newborns whose mothers received analgesia at delivery with butorphanol or nalbuphine compared to those who did not receive analgesia, although in both groups it occurred on average within the first hour after birth. (Crowell 1994)
There is a dosage and it is considered safe in the pediatric age group without causing respiratory depression. (Kubica 2015)
Unlike other opioids, its metabolites are inactive. (Martin 2018)
It can increase the secretion of prolactin. (Saarialho 1988)
Not available in several countries including Spain.