Last update July 23, 2022

N-acetylglucosamine

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Amino-monosaccharide that is a component of chitin, mucopolysaccharides and mucoproteins which is synthesized naturally in the body, found in cartilage, tendons and ligaments. Very abundant in seafood. It is used, without clearly scientific evidence of its efficacy, as an adjuvant treatment of osteoarthritis. (Rozendaal 2008)

N-acetylglucosamine is a derivative of glucosamine which is found naturally in breast milk. (Gudiel 2001, Miller 1994)

At latest update published were not found data on excretion in breast milk.

Its low bioavailability and rapid disappearance of the plasma stream makes it unlikely the pass into milk in significant amounts. It is a natural product with a very low toxic potential.

Expert authors consider the use of this medication safe during breastfeeding. (LactMed, Hale, Briggs 2015) 

The maximum daily amount of glucosamine as a food supplement should not exceed 500 mg. (AESAN 2011)

Alternatives

We do not have alternatives for N-acetylglucosamine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

N-acetylglucosamine is also known as Glucosamine. Here it is a list of alternative known names::


N-acetylglucosamine in other languages or writings:

Group

N-acetylglucosamine belongs to this group or family:

Tradenames

Main tradenames from several countries containing N-acetylglucosamine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 26 - 44 %
Molecular weight 179 daltons
Protein Binding 0 %
VD 0.04 l/Kg
pKa 11.7 -
0.3 - 2 hours

References

  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  2. The Royal Women’s Hospital Victoria Australia. Herbal and Traditional Medicines in Breasfeeding. Fact Sheet. 2013 Full text (link to original source) Full text (in our servers)
  3. AESAN. Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre condiciones de uso de determinadas sustancias distintas de vitaminas, minerales y plantas para ser empleadas en complementos alimenticios - 1. Revista del comité científico nº 17. 2012 Full text (in our servers)
  4. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract Full text (link to original source) Full text (in our servers)
  5. Rozendaal RM, Koes BW, van Osch GJ, Uitterlinden EJ, Garling EH, Willemsen SP, Ginai AZ, Verhaar JA, Weinans H, Bierma-Zeinstra SM. Effect of glucosamine sulfate on hip osteoarthritis: a randomized trial. Ann Intern Med. 2008 Abstract
  6. Gudiel-Urbano M, Goñi I. [Human milk oligosaccharides. The rule in the health and development of the infants]. Arch Latinoam Nutr. 2001 Abstract
  7. Setnikar I, Rovati LC. Absorption, distribution, metabolism and excretion of glucosamine sulfate. A review. Arzneimittelforschung. 2001 Abstract
  8. Miller JB, Bull S, Miller J, McVeagh P. The oligosaccharide composition of human milk: temporal and individual variations in monosaccharide components. J Pediatr Gastroenterol Nutr. 1994 Abstract
  9. Setnikar I, Palumbo R, Canali S, Zanolo G. Pharmacokinetics of glucosamine in man. Arzneimittelforschung. 1993 Abstract

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