Last update June 25, 2022

Molindone Hydrochloride

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

It is a typical, first generation antipsychotic with general properties similar to those of chlorpromazine, that is used for the treatment of schizophrenia and other psychoses. Oral or intramuscular administration.

Since the last update we have not found published data on its excretion in breastmilk.

The few known pharmacokinetic data do not allow to predict the possible passage into breast milk.

Product with very few bibliographical references and marketed in few countries.

It can cause galactorrhea. (Wesp 1979, Kahn 1979)

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives are preferable, especially during the neonatal period and in cases of prematurity.


See below the information of this related product:

Alternatives

  • Lurasidone (Safe substance and/or breastfeeding is the best option.)
  • Olanzapine (Safe substance and/or breastfeeding is the best option.)
  • Quetiapine Fumarate (Safe substance and/or breastfeeding is the best option.)
  • Ziprasidone (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Molindone Hydrochloride in other languages or writings:

Groups

Molindone Hydrochloride belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Molindone Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 313 daltons
pKa 15.43 -
Tmax 0.6 - 1.1 hours
T½ 2 hours

References

  1. Zetin M, Cramer M, Garber D, Plon L, Paulshock M, Hoffman HE, Schary WL. Bioavailability of oral and intramuscular molindone hydrochloride in schizophrenic patients. Clin Ther. 1985;7(2):169-75. Abstract
  2. Wesp CE Jr, Annitto W, Feinsod R. Galactorrhea associated with molindone. Am J Psychiatry. 1979 Jul;136(7):975. No abstract available. Abstract
  3. Kahn JL. More on galactorrhea associated with molindone. Am J Psychiatry. 1979 Dec;136(12):1617-8. No abstract available. Abstract

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