Last update March 29, 2023
Compatible
We do not have alternatives for Metrizamide since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Metrizamide in other languages or writings:
Main tradenames from several countries containing Metrizamide in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 0.4 | % |
Molecular weight | 789 | daltons |
pKa | 11.75 | - |
Tmax | 6 | hours |
T½ | 24 | hours |
Relative Dose | 0.02 | % |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
X-ray contrast medium with 48% iodine. It has been withhold from the market.
Metrizamide is excreted into breast milk in clinically non-significant amount, <0.1% of maternal dose. (Illet, 1981)
The various Iodinated contrast media for imaging examinations (X-rays, CT scans) are considered compatible with breastfeeding since they are rapidly eliminated with little or no release of iodine, not metabolized and virtually not absorbed when taken by mouth. They are structurally very similar to each other and one of them is their data no or minimal excretion in milk.
Given the low lipid solubility of the iodinated contrast, less than 1% of the dose administered to the mother just passing milk. Due to their low oral bioavailability, intestinal absorption is less than 1% of the dose that he may take the infant. The maximum dose just getting the baby is less than 0.01% of the maternal dose, which represents less than 1% of the dose administered to a nursing practice that is a radiological contrast examination.
Most experts and radiology scientific societies agree that after a radiological iodinated contrast examination is not necessary to wait no time to nurse.
American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)