Last update Nov. 10, 2022
Very Low Risk
It is an essential sulfur amino acid that is very abundant in eggs, meat and fish; sesame seeds, Brazil nuts, soybeans, legumes and cereal grains. It is used as an oral dietary supplement and in solutions for parenteral nutrition. It lowers urinary pH and is used in the treatment of urinary tract infections. The use of methionine as an antidote in the treatment of acetaminophen poisoning to prevent hepatotoxicity has been superseded by acetylcysteine. It is metabolised in the liver to ademetionine, and then homocysteine. Oral or intravenous administration.
At the date of the last update, we found no published data on its excretion in breast milk.
Methionine is found in breast milk, but in lower amounts (100 - 200 mg/L) than the other amino acids. (Lawrence 2016, Chavalittamrong 1981)
Authorized use in young infants for parenteral nutrition and treatment of paracetamol poisoning.
The daily requirements of methionine are 15 mg/kg of body weight: 750 to 1,200 mg/day. (FEN 2013, AESAN 2012). At these doses, methionine is compatible with breastfeeding.
High doses of oral methionine can produce elevated plasma homocysteine levels, nausea, vomiting, drowsiness, and irritability, and psychiatric symptoms in vulnerable people. (Martindale, Garlick 2006, Goren 2004)
We do not have alternatives for Methionine, L-Methionine, DL-Methionine since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM