Last update Oct. 13, 2022

Methicillin, Meticillin Sodium

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a penicillinase-resistant penicillin that is no longer used clinically because of its renal side effects. It has been used in the treatment of staphylococcal infections resistant to benzylpenicillin. It is inactivated by gastric acid and must be given by injection.

It is excreted in breast milk in clinically insignificant amounts. (LactMed)

The possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Benyamini 2005)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Group

Methicillin, Meticillin Sodium belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 420 daltons
Protein Binding 40 %
pKa 2.96 -
Tmax 0.5 - 1 hours
T½ 0.5 - 2 hours
Theoretical Dose 0.03 - 0.23 mg/Kg/d

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on March 15, 2022 Full text (link to original source)
  2. Benyamini L, Merlob P, Stahl B, Braunstein R, Bortnik O, Bulkowstein M, Zimmerman D, Berkovitch M. The safety of amoxicillin/clavulanic acid and cefuroxime during lactation. Ther Drug Monit. 2005 Abstract

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