Last update June 3, 2024

Methacycline Hydrochloride

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Methacycline is a semisynthetic broad-spectrum antibiotic, derived from and with uses similar to those of tetracycline, but with slower excretion. Oral administration twice daily.

At the time of the last update, we found no published data on its excretion in breast milk.

Tetracycline, similar in structure and properties to chlortetracycline, is considered compatible with breast-feeding.

Alternatives

  • Tetracycline (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Methacycline Hydrochloride in other languages or writings:

Group

Methacycline Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Methacycline Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 58 %
Molecular weight 479 daltons
Protein Binding 75 - 78 %
pKa 2.88 -
Tmax 3 hours
T½ 15 hours
M/P ratio 0.5 -

References

  1. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract

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