Last update Sept. 17, 2022


Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Metaxalone is a centrally acting skeletal muscle relaxant. It has sedative properties. Oral administration three or four times a day.

Since the last update we have not found published data on its excretion in breastmilk.

Its large volume of distribution could limit its excretion in breast milk.

Its effectiveness. is very limited. (Chou 2004)
Product with very few bibliographical references and marketed in very few countries.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


  • Ibuprofen (Safe substance and/or breastfeeding is the best option.)
  • Paracetamol (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Метаксалон is Metaxalone in Cyrillic.

Is written in other languages:


Метаксалон belongs to this group or family:


Main tradenames from several countries containing Метаксалон in its composition:


Variable Value Unit
Molecular weight 221 daltons
VD 11.4 l/Kg
pKa 13.14 -
Tmax 3.3 hours
9.0 ± 4.8 hours


  1. FDA. Metaxalone. Drug Summary. 2008 Full text (in our servers)
  2. Chou R, Peterson K, Helfand M. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage. 2004 Aug;28(2):140-75. Review. Abstract

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