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Meprobamate is a carbamate with hypnotic, sedative, and muscle relaxant properties. It is an active metabolite of Carisoprodol. It is used in anxiety disorders, insomnia, and spastic and painful musculoskeletal disorders. Oral administration in 3 to 4 daily doses.
It is excreted in breast milk (Sachs 2013, Bailey 2002, Wilson 1980), but in clinically insignificant amounts, and no problem has been observed in an infant whose mother was taking it. (Nordang 2001)
Meprobamate has a powerful sedative effect. It has been withdrawn from the market in numerous countries due to its poor risk/benefit ratio. (EMA 2012)
It is recommended to check for sedation and/or lack of appetite in infants (Sachs 2013). Bed-sharing (co-sleeping) with the baby is not recommended if this drug are used. (ABM 2020 y 2008, UNICEF 2018, 2017, 2014 y 2013, Landa 2012, UNICEF 2006)
Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.