Last update Aug. 20, 2022
A corticosteroid with a chemical structure and clinical effects similar to prednisone. It is a metabolite of methylprednisolone (Bago 2006). It has a predominantly glucocorticoidal action with little mineralocorticoidal action. Oral administration or injectable every 6 to 24 hours.
Since the last update date we have not found published data on its excretion in breastmilk.
Its high percentage of plasmatic protein binding makes it unlikely it will transfer to milk in significant amounts.
Other corticosteroids with a similar structure and actions are excreted in milk in insignificant amounts and are considered compatible with breastfeeding.
Corticosteroids are commonly used in pediatrics and lack side effects when they are used alone or in short-term treatments.
Meprednisone is marketed in few countries, It has very few bibliographical references and its pharmacokinetics are little known. (Gador 2011, Bago 2006)
Until there is more published data about this drug in relation to breastfeeding, safer alternatives may be preferred, especially during the neonatal period and in the case of prematurity.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
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