Last update Sept. 9, 2022

Mephenesine

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Mephenesin is a centrally acting skeletal muscle relaxant used for the symptomatic treatment of painful muscle spasm in some musculoskeletal diseases (Parkinson's, multiple sclerosis, cerebral palsy). Oral or topical cutaneous administration in several daily doses.

Since the last update we have not found published data on its excretion in breastmilk.

The few known pharmacokinetic data do not allow to predict its possible extraction in breast milk.

The potential side effects are serious (sedation, vomiting and respiratory arrest) and there is a risk of abuse and dependency. (Fanton 2007, Prescrire 2013)

The literature on this drug is scarce, and it is sold in few countries.

Can be used topically but avoid applying it on the breast.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Baclofen ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Carisoprodol (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Methocarbamol (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Mephenesine is also known as


Mephenesine in other languages or writings:

Group

Mephenesine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Mephenesine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Alta - Hig %
Molecular weight 182 daltons

References

  1. [No authors listed] Mephenesin: abuse and dependence. Prescrire Int. 2013 May;22(138):127-8. Abstract
  2. Fanton L, Bévalot F, Schoendorff P, Le Meur C, Gaillard Y, Malicier D. Fatal mephenesin intoxication. J Forensic Sci. 2007 Jan;52(1):221-3. Abstract

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