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Mepacrine is an antiprotozoal used as an alternative to nitroimidazoles in the treatment of giardiasis, in the treatment of some forms of lupus erythematosus, of cutaneous leishmaniasis, as a sterilization technique for contraception, and in the management of malignant pleural effusions. It was used as an antimalarial and is under investigation in Creutzfeldt-Jakob disease. Oral administration.
At the date of the last update, we found no published data on its excretion in breast milk.
Its pharmacokinetic data (high percentage of protein binding, moderately high molecular weight and wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk, but its long elimination half-life would facilitate this.
The most common adverse effects are dizziness, headache, and gastrointestinal disturbances such as nausea and vomiting; psychiatric symptoms may appear. (Martindale, Mørch 2020, Chaudhuri 1946)
It is sold in very few countries.
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.