Last update June 28, 2022
Limited compatibility
We do not have alternatives for Memantine Hydrochloride.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Memantine Hydrochloride in other languages or writings:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 100 | % |
Molecular weight | 179 | daltons |
Protein Binding | 45 | % |
VD | 10 | l/Kg |
pKa | 10.7 | - |
Tmax | 3 - 8 | hours |
T½ | 60 - 100 | hours |
Write us at elactancia.org@gmail.com
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
It is a derivative of amantadine. It is used in the treatment of Alzheimer's disease, parkinsonism and central spasticity and other brain injuries or comatose states. Oral administration once or twice daily.
Since the last update we have not found published data on its excretion in breastmilk.
Its low molecular weight and low binding to plasma proteins would facilitate its excretion in breast milk, while its high volume of distribution would make it difficult.
For some authors it is an expendable product, with a negative risk/benefit ratio. (Prescrire 2018)
It may cause drowsiness, dizziness, hypertension, dyspnea, constipation, headache, and liver function abnormalities. (AEMPS 2020)