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Pentavalent antimony compounds, such as sodium stibogluconate or meglumine antimoniate, are used as first-line treatment for most forms of leishmaniasis: Intramuscular, intravenous or intralesional administration.
The few pharmacokinetic data known do not allow predicting its possible excretion in breast milk.
Its low oral bioavailability makes it difficult to pass into infant plasma from ingested breast milk, except in premature infants and the immediate neonatal period where there may be greater intestinal permeability.
Authorized for use in pediatrics, even in small infants.
A 4-year-old breastfed girl had severe perioral and oral lesions due to maternal nipple-areola lesions at 3 months of age. She was successfully treated with sodium stibogluconate and meglumine antimoniate. (Costa 1988)
List of essential medicines WHO: compatible with breastfeeding (WHO-UNICEF 2002). American Academy of Pediatrics: antimony compounds are a medication that is generally compatible with breastfeedin. (AAP 2001)