Last update Oct. 21, 2023

Meclofenamic Acid

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a low potency non-steroidal anti-inflammatory drug (NSAID) derived from anthranilic acid similar to mefenamic acid. It is used to treat mild to moderate pain in rheumatoid arthritis and osteoarthritis, dysmenorrhea and menorrhagia. It is administered orally in 3 to 4 daily doses.

On latest update no published data about breastfeeding were found

Its high plasma protein binding makes excretion into breast milk unlikely

Until more information on this drug concerning breastfeeding is available, a safer alternative is preferred.


  • Ibuprofen ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Mefenamic Acid ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Paracetamol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Meclofenamic Acid is also known as

Meclofenamic Acid in other languages or writings:


Main tradenames from several countries containing Meclofenamic Acid in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 296 / 336 daltons
Protein Binding > 99 %
VD 0.13 - 0.62 l/Kg
pKa 3.79 -
Tmax 0.5 - 2 hours
0.8 - 5.3 (Metabol: 15) hours


  1. Mylan Ph. Meclofenamate sodium. Drug Summary. 2021 Full text (in our servers)
  2. Conroy MC, Randinitis EJ, Turner JL. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991 Abstract

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