Last update Nov. 8, 2022

Mannose; D-Mannose

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Mannose is a monosaccharide, epimer of glucose, widely distributed in body fluids and tissues. It is part of some plant polysaccharides, such as mannan and glucomannan, and of some animal glycoproteins. It is not an essential nutrient as it is produced in the body from glucose. It is used to synthesize glycoproteins and produce energy. Mannose is used as a nutritional supplement and, with a lack of conclusive evidence, to prevent recurrent urinary tract infections. Oral administrationl. (Cooper 2022, De Nunzio 2021, Kyriakides 2021, Lenger 2020, Wei 2020)

At the date of the last update, we found no published data on its excretion in breast milk.

D-mannose is a sugar part of normal human metabolism found within most diets. Adverse effects are rare and not serious: diarrhea and vaginal burning. (Cooper 2022)

Given its lack of toxicity, its consumption at the indicated doses is compatible with breastfeeding.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Mannose; D-Mannose is also known as

Mannose; D-Mannose in other languages or writings:


Mannose; D-Mannose belongs to this group or family:


Main tradenames from several countries containing Mannose; D-Mannose in its composition:

  • Cistiseid™. Contains other elements than Mannose; D-Mannose in its composition
  • Cysticlean™. Contains other elements than Mannose; D-Mannose in its composition


Variable Value Unit
Molecular weight 180 daltons
pKa 12.26 -


  1. Cooper TE, Teng C, Howell M, Teixeira-Pinto A, Jaure A, Wong G. D-mannose for preventing and treating urinary tract infections. Cochrane Database Syst Rev. 2022 Aug 30;8:CD013608. Consulted on Nov. 8, 2022 Abstract Full text (link to original source)
  2. Kyriakides R, Jones P, Somani BK. Role of D-Mannose in the Prevention of Recurrent Urinary Tract Infections: Evidence from a Systematic Review of the Literature. Eur Urol Focus. 2021 Sep;7(5):1166-1169. Abstract
  3. De Nunzio C, Bartoletti R, Tubaro A, Simonato A, Ficarra V. Role of D-Mannose in the Prevention of Recurrent Uncomplicated Cystitis: State of the Art and Future Perspectives. Antibiotics (Basel). 2021 Apr 1;10(4). pii: 373. Abstract Full text (link to original source)
  4. Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020 Aug;223(2):265.e1-265.e13. Abstract Full text (link to original source)
  5. Wei Z, Huang L, Cui L, Zhu X. Mannose: Good player and assister in pharmacotherapy. Biomed Pharmacother. 2020 Sep;129:110420. Abstract Full text (link to original source)

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