Last update Aug. 20, 2022

Manidipine Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a dihydropyridine-type calcium channel blocker. It is used in the treatment of hypertension. Oral administration once daily.

At latest update no published data were found on excretion into breast milk.

Its high plasma protein binding capacity makes it unlikely any passage to the breast milk, however, its high lipid solubility (Rosillon 1998) facilitates excretion into it.

Oral bioavailability is increased when administered with a fatty meal (Rosillon 1998), which would increase the oral absorption in the infant.

Evidence on other antihypertensive drugs of the same family and similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.
Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Manidipine Hydrochloride is also known as


Manidipine Hydrochloride in other languages or writings:

Group

Manidipine Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Manidipine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 684 daltons
Protein Binding 99 %
VD 19.47 l/Kg
Tmax 1.5 hours
4 - 8 hours

References

  1. PRD-ANSM. Manidipine. Drug Summary 2012 Full text (in our servers)
  2. AEMPS. Manidipino. Ficha ténica. 2011 Full text (in our servers)
  3. Rosillon D, Stockis A, Poli G, Acerbi D, Lins R, Jeanbaptiste B. Food effect on the oral bioavailability of Manidipine: single dose, randomized, crossover study in healthy male subjects. Eur J Drug Metab Pharmacokinet. 1998 Abstract

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