Last update Jan. 2, 2022

M01AB03; M02AA21

Compatible

Safe substance and/or breastfeeding is the best option.

It is a non-steroidal anti-inflammatory drug (NSAID). Indicated in joint and musculoskeletal pain, osteoarthritis and rheumatoid arthritis. Oral administration in three daily doses.

It is excreted in breast milk in clinically insignificant amounts.(Sagraves 1985)

American Academy of Pediatrics: medication usually compatible with breastfeeding. (AAP 2001)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Ibuprofen (Safe substance and/or breastfeeding is the best option.)
  • Paracetamol (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

M01AB03; M02AA21 is Tolmetin Sodium in ATC Code/s.

Is written in other languages:

Tradenames

Main tradenames from several countries containing M01AB03; M02AA21 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 315 daltons
Protein Binding 99 %
pKa 3.96 -
Tmax 1 hours
1.5 hours
M/P ratio 0.01 -
Theoretical Dose 0.027 mg/Kg/d
Relative Dose 0.27 %
Ped.Relat.Dose 0.06 - 0.1 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Sagraves R, Waller ES, Goehrs HR. Tolmetin in breast milk. Drug Intell Clin Pharm. 1985 Jan;19(1):55-6. No abstract available. Abstract

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