Last update April 16, 2024

Lisinopril

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Lisinopril is an angiotensin-converting enzyme inhibitor (ACEI) used in the treatment of hypertension, heart failure and diabetic nephropathy and as prophylaxis after myocardial infarction. Oral administration once a day.

At the time of the last update, we found no published data on its excretion in breast milk.

Other compounds in the same group (ACEI) are not significantly excreted in breast milk, but until further published data on this drug in relation to breastfeeding are known safer alternatives may be preferable. (Hale, LactMed, Anderson 2018, Malachias 2016)

Due to its potential renal toxicity in premature infants, it is preferable to avoid its use during the neonatal period in case of prematurity. (Serrano 2015)

The protective role of breastfeeding against maternal hypertension has been proven. (Park 2018)

Alternatives

  • Captopril (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Lisinopril in other languages or writings:

Groups

Lisinopril belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Lisinopril in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 (6 - 60) %
Molecular weight 442 daltons
Protein Binding 0 %
pKa 3.17 -
Tmax 7 hours
T½ 12.6 hours

References

  1. Park S, Choi NK. Breastfeeding and Maternal Hypertension. Am J Hypertens. 2018 Abstract
  2. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  3. AEMPS. Lisinopril. Ficha técnica. 2017 Full text (in our servers)
  4. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source)
  5. Astra-Zeneca. Lisinopril. Drug Summary. 2012 Full text (in our servers)

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