Lisdexamfetamine dimesylate

A prodrug that is metabolized directly in the intestine to dextroamphetamine. It is used to treat Attention Deficit Hyperactivity Disorder (ADHD) and bulimia. Dextroamfetamine is a sympathomimetic drug, central nervous system stimulant, whose action and uses are similar to amphetamine (see information) which is its dextro isomer. Oral administration.

Dextroamfetamine is excreted in breast milk, concentrating about 3 times more than in plasma. This concentration assumes a relative dose about 6% ^{(Ilett, 2007)}

In infants whose mothers were taking dexamfetamine as treatment for ADHD, levels ranging from undetectable to 14% of maternal plasma levels have been measured and no problems were observed in the clinical follow-up of these infants. ^{(Ilett, 2007)}

There is little information on the impact of amphetamine abuse on the development and health of infants ^{(Oei, 2012, Wise, 2007; Moretti, 2000)}, but it is known that they are more exposed to social problems, domestic violence, and lower breastfeeding rates. ^{(Oei, 2010)}

There is controversy over the possibly mild negative effect of amphetamine on prolacti^{n (Petraglia, 1987; DeLeo, 1983)}, but milk production in mothers who took it therapeutically was not affected. ^{(Öhman, 2015)}

During breastfeeding, the therapeutic use (narcolepsy, ADHD) of dexamphetamine can be assessed, using the lowest possible effective dose and monitoring the occurrence of irritability, insomnia, lack of appetite and weight loss. Some authors contraindicate it. ^{(Ornoy 2018)}

Its use as an illegal drug is totally discouraged. ^{(Oei, 2012).} 

To minimize the risk, after the last recreational use of amphetamine, it is advisable to wait 55 hours (5 T ½, which eliminates 97% of the substance) before breastfeeding again. Meanwhile, express and discard milk from the breast regularly to maintain production.

See below the information of these related products:

• Amfetamine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
• Dexamfetamine Sulfate (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
• Narcolepsy. Narkolepsy. (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)