Last update Feb. 19, 2015


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Non-opioid cough relief medication.

At latest update, relevant published data on excretion into breast milk were not found.

Pharmacokinetic characteristics (low molecular weight, low protein-binding capacity) would favour that it may be excreted into breast milk in significant amount.

Until more information on it is available, safer options are preferred, especially when the infant is a newborn or in case of prematurity.

Otherwise whenever used, the lower effective dose as possible and for the shortest time is recommended. Follow-up for somnolence and feeding troubles should be warranted.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Variable Value Unit
Oral Bioavail. 75 %
Molecular weight 236 daltons
Protein Binding 11 - 14 %
VD 3.4 l/Kg
Tmax 0.4 - 0.9 hours
21 - 2 hours


  1. AEMPS. Levodropropizina. Ficha técnica. 2014 Full text (in our servers)
  2. Levodropropizine. Drug Summary. 2014 Full text (in our servers)
  3. Jang JW, Seo JH, Jo MH, Lee YJ, Cho YW, Yim SV, Lee KT. Relative bioavailability of levodropropizine 60 mg capsule and syrup formulations in healthy male Korean volunteers: a singledose, randomized-sequence, open-label, two-way crossover study. Int J Clin Pharmacol Ther. 2013 Abstract
  4. Sangil Jeon, Jongtae Lee, Taegon Hong, Jeongki Paek, Seunghoon Han, Dong-Seok Yim. Pharmacokinetics and Safety of Levodropropizine Controlled Release Tablet after Repeated Dosing in Healthy Male Volunteers. J Korean Soc Clin Pharmacol Ther 2013;21(2):113-119. 2013 Full text (link to original source) Full text (in our servers)
  5. Banderali G, Riva E, Fiocchi A, Cordaro CI, Giovannini M. Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough. J Int Med Res. 1995 Abstract

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