Last update Dec. 26, 2024

Levodropropizine; Dropropizine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Dropropizine and its isomer levodropropizine are peripherally acting non-opioid suppressants of non-productive cough. They are administered orally three or four times a day.

At the date of last update we found no published data on its excretion in breast milk.

Its pharmacokinetic data (low molecular weight, low binding to plasma proteins) make it likely to pass into milk in an amount that could be significant.

Its possible side effects are neither frequent nor serious: fatigue, drowsiness, nausea, diarrhea... (XFarma 2024, AEMPS 2014)

Product with very few bibliographic references and/or very old, marketed in few countries.
Until more published data on this drug in relation to breastfeeding are known, safer alternatives may be preferable, especially during the neonatal period and in case of prematurity.

If used in breastfeeding it is advisable to use the lowest effective dose and for the shortest possible time. Monitor drowsiness and adequate feeding of the infant.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Levodropropizine; Dropropizine in other languages or writings:

Group

Levodropropizine; Dropropizine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Levodropropizine; Dropropizine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 75 %
Molecular weight 236 daltons
Protein Binding 11 - 14 %
VD 3.4 l/Kg
Tmax 0.4 - 0.9 hours
21 - 2 hours

References

  1. XFarma Levodropropizine. Drug Summary. 2024 Full text (in our servers)
  2. AEMPS. Levodropropizina. Ficha técnica. 2014 Full text (in our servers)
  3. Jang JW, Seo JH, Jo MH, Lee YJ, Cho YW, Yim SV, Lee KT. Relative bioavailability of levodropropizine 60 mg capsule and syrup formulations in healthy male Korean volunteers: a singledose, randomized-sequence, open-label, two-way crossover study. Int J Clin Pharmacol Ther. 2013 Abstract
  4. Sangil Jeon, Jongtae Lee, Taegon Hong, Jeongki Paek, Seunghoon Han, Dong-Seok Yim. Pharmacokinetics and Safety of Levodropropizine Controlled Release Tablet after Repeated Dosing in Healthy Male Volunteers. J Korean Soc Clin Pharmacol Ther 2013;21(2):113-119. 2013 Full text (link to original source) Full text (in our servers)
  5. Banderali G, Riva E, Fiocchi A, Cordaro CI, Giovannini M. Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough. J Int Med Res. 1995 Abstract

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