Last update Oct. 9, 2016

Leucine

Compatible

Safe substance and/or breastfeeding is the best option.

Leucine, isoleucine and valine are essential amino acids which are not produced by the body and must be ingested from the diet.
They are found in large amount in muscles of meat and are necessary for synthesis of proteins in the body.
They are wasted during liver disorders, high catabolic processes (cancer, burns) and also used for dietary supplementation in sport and fitness.

At latest update no published data on excretion into breast milk were found.
Around 20 amino acids (8 of them are essential) are normally present in breastmilk to which they reach through a selective-transport system of alveolar mammary epithelium (Ramirez 2001) with higher concentrations observed in the milk of obese mothers ( De Luca 2016).
Its concentration is higher in the plasma of both mother and newborn after vaginal delivery than after cesarean section. (Schulpis 2009).
BCAA supplementation does not alter the levels of prolactin (Bianchi 1992).

These are natural components of the body that are devoid of toxicity even at higher doses than those recommended (AESAN 2012) without harmful effect while breastfeeding.

Alternatives

We do not have alternatives for Leucine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Leucine is also known as Branched-Chain Amino Acids (BCAAs). Here it is a list of alternative known names::


Leucine in other languages or writings:

Groups

Leucine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Leucine in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 117 - 131 daltons

References

  1. De Luca A, Hankard R, Alexandre-Gouabau MC, Ferchaud-Roucher V, Darmaun D, Boquien CY. Higher concentrations of branched-chain amino acids in breast milk of obese mothers. Nutrition. 2016 Abstract
  2. FEN - Fundación Española de la Nutrición. Libro Blanco de la Nutrición en España. - 2013 Full text (link to original source)
  3. AESAN. Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre condiciones de uso de determinadas sustancias distintas de vitaminas, minerales y plantas para ser empleadas en complementos alimenticios - 1. Revista del comité científico nº 17. 2012 Full text (in our servers)
  4. Schulpis KH, Vlachos GD, Papakonstantinou ED, Karikas GA, Vlachos DG, Roma E, Antsaklis A, Papassotiriou I, Tsakiris S. Maternal-neonatal amino acid blood levels in relation to the mode of delivery. Acta Obstet Gynecol Scand. 2009 Abstract
  5. Ramirez I, DeSantiago S, Tovar AR, Torres N. Amino acid intake during lactation and amino acids of plasma and human milk. Adv Exp Med Biol. 2001 Abstract
  6. Bianchi GP, Marchesini G, Zoli M, Abbiati R, Ferrario E, Fabbri A, Pisi E. Oral BCAA supplementation in cirrhosis with chronic encephalopathy: effects on prolactin and estradiol levels. Hepatogastroenterology. 1992 Abstract

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