Last update April 29, 2022

Кетопрофен

Compatible

Safe substance and/or breastfeeding is the best option.

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID). Oral, rectal, intramuscular, intravenous and topical administration every 6 to 12 hours.

It is excreted in breastmilk in clinically negligibe amounts (Jacqz-Aigrain 2007) and expert authors consider it compatible with breastfeeding (Hale, Davanzo 2014, Jacqz-Aigrain 2007, Janssen 2000, Nice 2000). Its high percentage of protein binding explains the very small transfer to milk observed.

In a French pharmacovigilance study, several possible cases, unconfirmed, were found of the implication of ketoprofen in certain adverse effects in the infant (Soussan 2014). Its pharmacokinetics makes its involvement unlikely.

Most non-steroidal anti-inflammatories may increase jaundice, so it is preferable to avoid them during the neonatal period in mothers of infants with jaundice. (Janssen 2000)

TOPICAL USE: The small dose and the low plasma absorption of most topical dermatological preparations make transfer to breastmilk in significant amounts unlikely. Dermal bioavailability is 5%. (AEMPS 2016)

 


See below the information of this related product:

Alternatives

  • Ibuprofen (Safe substance and/or breastfeeding is the best option.)
  • Paracetamol (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Кетопрофен is Ketoprofen in Cyrillic.

Is written in other languages:

Groups

Кетопрофен belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Кетопрофен in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 (Derm: 5%) %
Molecular weight 254 daltons
Protein Binding 99 %
VD 0.1 l/Kg
pKa 4.45 -
Tmax 0.5 - 4 hours
T½ 1.5 - 4 hours
Theoretical Dose 0.009 (0.003 a 0.021) mg/Kg/d
Relative Dose 0.3 (0.14 - 0.48) %

References

  1. AEMPS. Ketoprofeno. Ficha técnica. 2017 Full text (in our servers)
  2. AEMPS. Ketoprofeno (uso tópico). Ficha técnica. 2016 Full text (in our servers)
  3. Soussan C, Gouraud A, Portolan G, Jean-Pastor MJ, Pecriaux C, Montastruc JL, Damase-Michel C, Lacroix I. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014 Abstract
  4. Davanzo R, Bua J, Paloni G, Facchina G. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014 Abstract
  5. Cherif F, El Aidli S, Kastalli S, Zaiem A, Daghfous Moula H, Lakhal M, Daghfous R. Drug induced urticaria via breastfeeding. in; Abstracts of the 13th Annual Meeting of French Society of Pharmacology and Therapeutics, 76th Annual Meeting of Society of Physiology, 30th Pharmacovigilance Meeting, 10th APNET Seminar and 7th CHU CIC Meeting, 15‐17 April 2009, Marseille, France Fundam Clin Pharmacol. 2009;23 (Suppl 1):37. Abstract 203
  6. Jacqz-Aigrain E, Serreau R, Boissinot C, Popon M, Sobel A, Michel J, Sibony O. Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. Ther Drug Monit. 2007 Abstract
  7. Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med. 2000 Abstract Full text (link to original source) Full text (in our servers)
  8. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  9. De Graeve J, Frankinet C, Gielen JE. A quantitative selected ion monitoring assay for ketoprofen determination in human biological fluids. Biomed Mass Spectrom. 1979 Abstract

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