Last update Nov. 14, 2014


High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Seemingly a sympathomimetic drug with poor effect on Migraine relief.

On latest update relevant data on breastfeeding was not found.

Because a low excretion into breast milk Sumatriptan is a preferred drug.

Other medication for Migraine relief like Triptans, Ibuprofen, Diclofenac and Ketorolate are more effective and at a lower risk for breastfeeding than Isometheptene.


  • Eletriptan Hydrobromide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Sumatriptan ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Zolmitriptan (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Isometheptene belongs to this group or family:


Main tradenames from several countries containing Isometheptene in its composition:


Variable Value Unit
Molecular weight 493 daltons


  1. Duong S, Bozzo P, Nordeng H, Einarson A. Safety of triptans for migraine headaches during pregnancy and breastfeeding. Can Fam Physician. 2010 Abstract Full text (link to original source) Full text (in our servers)
  2. Jürgens TP, Schaefer C, May A. Treatment of cluster headache in pregnancy and lactation. Cephalalgia. 2009 Abstract
  3. Beseler-Soto B, Paricio-Talayero JM, Sánchez-Palomares M, Benlloch-Muncharaz M, Santos-Serrano L, Landa-Rivera L. MIgraña en la mujer. [Migraine and female]. Rev Neurol. 2008 Abstract
  4. Raña-Martínez N. Migraña en la mujer. [Migraine in females]. Rev Neurol. 2008 Abstract
  5. Marcus DA. Managing headache during pregnancy and lactation. Expert Rev Neurother. 2008 Abstract
  6. MacGregor EA. Migraine in pregnancy and lactation: a clinical review. J Fam Plann Reprod Health Care. 2007 Abstract Full text (in our servers)
  7. Loder E. Migraine in pregnancy. Semin Neurol. 2007 Abstract
  8. Sances G, Granella F, Nappi RE, Fignon A, Ghiotto N, Polatti F, Nappi G. Course of migraine during pregnancy and postpartum: a prospective study. Cephalalgia. 2003 Abstract
  9. Wojnar-Horton RE, Hackett LP, Yapp P, Dusci LJ, Paech M, Ilett KF. Distribution and excretion of sumatriptan in human milk. Br J Clin Pharmacol. 1996 Abstract Full text (link to original source) Full text (in our servers)

Total visits


Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM