Ινδομεθακίνη

It is a non-steroidal anti-inflammatory drug (NSAID), derived from indole acetic acid, which is used for the symptomatic treatment of chronic musculoskeletal pain, to induce closure of a patent ductus arteriosus in premature babies and, topically, in certain ophthalmological processes. Oral, rectal or eye drop administration in three daily doses.

It is excreted into breast milk in non-significant clinically amounts. Usually, breast milk and infant plasma levels have been found to be undetectable. ^{(Beaulac 1993, Lebedevs 1991)}

There has not been side-effects described in children from treated mothers ^{(Li 1994, Lebedevs 1991)}, except for a case reported in 1978 with convulsions in a newborn infant whose mother received a higher dose than recommended ^{(Eeg 1978)}. However, a causal relationship was questioned by other author in the same publication.

It has been successfully used with no side-effects on treated mothers who had high levels of Prostaglandin E (PGE) whose infants were suffering of “physiologic diarrhea. ^{(Li 1994)}

This drug is used in neonates. Expert authors consider the use of this medication probably compatible during breastfeeding. ^{(Hale, LactMed, Bordini 2016, Briggs 2015, Risser 2009, Østensen 2007, Nice 2004, Lee 1993)}. The American Academy of Pediatrics rates it as usually compatible with breastfeeding. ^{(AAP 2001)}

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.