Last update Aug. 7, 2019

Human Osteogenic Protein

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Osteoinductive proteins that cause the formation of bone tissue at the implant site.
They belong to the family of transforming growth factors TGF-beta (TGF-β) (Gálvez 2004).
Indicated as a substitute for bone graft in fusion of lumbar vertebrae and in acute tibial fractures.
Surgical administration as a local implant.

Since the last update we have not found published data on its excretion in breastmilk.

Its high molecular weight and the fact that no systemic distribution has been detected after implantation and its half-life of a few minutes (EMA 2012, p5.2) make its excretion in breastmilk very unlikely.

Zero oral bioavailability is anticipated which would impede its transfer from breastmilk into infant plasma since, due to its protein nature, it degrades in the gastrointestinal tract, and is not absorbed.

Alternatives

We do not have alternatives for Human Osteogenic Protein.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Human Osteogenic Protein is also known as Bone Morphogenetic Proteins (BMP). Here it is a list of alternative known names::


Human Osteogenic Protein in other languages or writings:

Group

Human Osteogenic Protein belongs to this group or family:

Tradenames

Main tradenames from several countries containing Human Osteogenic Protein in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 30.000 daltons
(0.1) hours

References

  1. EMA-Medtronic. Dibotermina alfa (InductOs). Ficha técnica. 2012 Full text (in our servers)
  2. EMA-Medtronic. Dibotermin alfa (InductOs). Drug Summary. 2012 Full text (in our servers)
  3. EMA-Olympus. Eptotermina (Osigraft). Ficha técnica. 2011 Full text (in our servers)
  4. EMA-Olympus. Eptotermin (Osigraft). Drug Summary 2011 Full text (in our servers)
  5. FDA-Medtronic. Infuse Bone Graft. Drug Summary. 2004 Full text (in our servers)
  6. Gálvez-Gastélum FJ, Sandoval-Rodríguez AS, Armendáriz-Borunda J. El factor de crecimiento transformante β como blanco terapéutico. [Transforming growth factor-beta as a therapeutic target]. Salud Publica Mex. 2004 Jul-Aug;46(4):341-50. Review. Spanish. Abstract Full text (link to original source) Full text (in our servers)

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