Last update Feb. 10, 2019

حمض بيبيميديك

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Antibiotic of the quinolone type, active in vitro against Pseudomonas aeruginosa, structurally related to nalidixic acid.
It has been used orally and intravenously (two daily doses) to treat urinary tract infections from Gram-negative bacteria (Shimizu M 1975).

SInce the last update we have not found published data on its excretion in breastmilk.

Low toxicity in humans has been reported (Azierta 2016).

This product has very few bibliographical references.

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity or glucose-6-phosphate dehydrogenase deficiency.

The possible negativity of cultures in febrile infants whose mothers take antibiotics should be taken into account, as well as the possibility of gastroenteritis due to alteration of the intestinal flora (Ito 1993).


See below the information of this related product:

  • Nalidixic Acid (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

  • Ciprofloxacin (Safe product and/or breastfeeding is the best option.)
  • Norfloxacin (Safe product and/or breastfeeding is the best option.)
  • Ofloxacin (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

حمض بيبيميديك is Pipemidic Acid in Arabic.

Is written in other languages:

حمض بيبيميديك is also known as

Group

حمض بيبيميديك belongs to this group or family:

Tradenames

Main tradenames from several countries containing حمض بيبيميديك in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 93 %
Molecular weight 303 daltons
Protein Binding 39 %
VD 1.7 l/Kg
Tmax 1.1 hours
T½ 3.5 hours

References

  1. Azierta. Pipemidic acid. Drug Summary. 2016 Full text (in our servers)
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  3. Klinge E, Männistö PT, Mäntylä R, Mattila J, Hänninen U. Single- and multiple-dose pharmacokinetics of pipemidic acid in normal human volunteers. Antimicrob Agents Chemother. 1984 Abstract
  4. Shimizu M, Nakamura S, Takase Y, Kurobe N. Pipemidic acid: absorption, distribution, and excretion. Antimicrob Agents Chemother. 1975 Abstract
  5. Shimizu M, Takase Y, Nakamura S, Katae H, Minami A. Pipemidic acid, a new antibacterial agent active against Pseudomonas aeruginosa: in vitro properties. Antimicrob Agents Chemother. 1975 Abstract

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