Last update June 4, 2024

Halothane

Compatible

Safe substance and/or breastfeeding is the best option.

Halothane is a general inhalation gas anesthetic sthetic gas similar to enflurane, methoxyflurane, and isoflurane, used for the induction and maintenance of general anesthesia.

Minimal concentrations of halothane have been measured in human breast milk (Con 1976).

The elimination half-life of halothane is unknown, although it accumulates in adipose tissue and is eliminated for several days.

It is not known whether it is absorbed orally.

Shorter acting anesthetics are preferable.

Exeprt authors consider it probably compatible with breastfeeding. (Hale, Brigs 2015, Howie 2006, Hale 1999, Lee 1993)

American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)

Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)

Alternatives

  • Sevoflurane (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Halothane in other languages or writings:

Group

Halothane belongs to this group or family:

Tradenames

Main tradenames from several countries containing Halothane in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 197 daltons
Tmax 0.3 hours
M/P ratio 3.5 -

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. INSHT-Instituto Nacional de Seguridad e Higiene en el Trabajo. Ventilación general en hospitales. Notas Técnicas de Prevención. 2010 Full text (link to original source) Full text (in our servers)
  4. Howie WO, McMullen PC. Breastfeeding problems following anesthetic administration. J Perinat Educ. 2006 Abstract Full text (link to original source) Full text (in our servers)
  5. Nice FJ, De Eugenio D, Dimino TA, Freeny IC, Rovnack MB, Gromelski JS. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and Other Healthcare Professionals. Part I. J Pharm Technol 2004;20:17-27. doi: 10.1177/875512250402000106.
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  7. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  8. MSC-Ministerio de Sanidad y consumo. España. Agentes anestésicos inhalatorios. Protocolos de vigilancia específica. 2001 Full text (link to original source) Full text (in our servers)
  9. Hale TW. Anesthetic medications in breastfeeding mothers. J Hum Lact. 1999 Sep;15(3):185-94. Review. No abstract available. Abstract
  10. Lee JJ, Rubin AP. Breast feeding and anaesthesia. Anaesthesia. 1993 Jul;48(7):616-25. Review. Abstract Full text (link to original source) Full text (in our servers)
  11. Coté CJ, Kenepp NB, Reed SB, Strobel GE. Trace concentrations of halothane in human breast milk. Br J Anaesth. 1976 Abstract Full text (link to original source) Full text (in our servers)

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