Last update Nov. 14, 2023

Haemophilus influenzae (Hib) vaccines

Compatible

Safe product and/or breastfeeding is the best option.

Haemophilus influenzae vaccines are used for active immunization against Haemophilus influenzae type b (Hib) infections: meningitis, pneumonia, epiglottitis, cellulitis and osteoarthritis. The vaccines contain HIb capsular polysaccharide. Immune response is enhanced by attaching the polysaccharide to a carrier protein (e.g. diphtheria or tetanus toxoid) to form a conjugate vaccine. Intramuscular administration.

Women vaccinated during pregnancy had higher levels of HIb antibodies in colostrum and milk than unvaccinated women. (Insel 1985)

Breastfeeding has been found to increase the rate of specific antibodies after HIb vaccination in some studies (Silfverdal 2007, Pabst 1990), but there have been no differences in other published studies. (Scheifele 1992)

Among infants vaccinated against HIb, breastfed infants had lower IgG titers than formula-fed infants, but there were no invasive HIb infections in any of the infants in the study. (Hawkes 2007)​

Several medical societies and expert authors consider safe to use this vaccine during lactation. (CDC 2023 and 2011, Red Book 2021-2024 p108-9, CAV-AEP 2019, Lawrence 2016 p402, Taylor 2003, Briggs 2015, Sachs 2013, Raney 2012, Chen 2010, WHO 2002).

VACCINES AND BREASTFEEDING:

(RedBook 2021-2024, CDC 2023, 2011 y 2000, Taylor 2019, Lawrence 2016 p402, Sachs 2013, Munoz 2013, Raney 2012, Perin 2012, Gall 2012, Chen 2010, Pisacane 2010, Schmidt 2004, López 2002, Pickering 1998, Pabst 1997, Hahn 1990)

Vaccines are compatible with lactation, both live attenuated microorganisms and killed, inactivated or formed by parts or toxoids of the same or generated by recombinant technology.

They do not pass into milk, except for rubella, which does not usually infect the infant or only mildly, and do not cause problems in infants, except for yellow fever in infants under 6 months of age. 

Breastfeeding may improve the antibody response of vaccines and cause fewer side effects such as fever or anorexia. 

Immediate postpartum is the best time to vaccinate measles-rubella-mumps and varicella in women who were not immunized.

Breastfeeding women can and should be protected with the recommended vaccines as other adults.

Breastfed infants should be immunized according to the appropriate immunization schedule.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

Haemophilus influenzae (Hib) vaccines in other languages or writings:

Group

Haemophilus influenzae (Hib) vaccines belongs to this group or family:

Tradenames

Main tradenames from several countries containing Haemophilus influenzae (Hib) vaccines in its composition:

List of 8 tradenames

References

  1. CDC- ACIP. Vaccine Recommendations and Guidelines of the ACIP. Special Situations. Breastfeeding and Vaccination. - 2023 Consulted on Oct. 25, 2023 Full text (link to original source)
  2. CDC - Centers for Disease Control and Prevention. Vaccination Safety for Breastfeeding Mothers. Breastfeeding and Special Circumstances. 2023 Full text (link to original source) Full text (in our servers)
  3. (Red Book). AAP. Kimberlin DW, Barnett ED, , Lynfield R, Sawyer MH eds. Red Book: 2021-2024. Report of the Committee on Infectious Diseases. 32th ed. Elk Grove Village, - 2021
  4. CAV-AEP. Comité asesor de vacunas de la Asociación Española de Pediatría. Lactancia materna y vacunas. None 2019 Full text (link to original source) Full text (in our servers)
  5. Taylor CM, Shelton CM. Vaccine recommendations in pregnancy and lactation. J Am Pharm Assoc (2003). 2019 Jan - Feb;59(1):137-140. Abstract
  6. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  7. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  8. Raney EC, El-Ibiary SY. Immunizations and pregnancy: an update for pharmacists. J Am Pharm Assoc (2003). 2012 Abstract
  9. CDC. National Center for Immunization and Respiratory Diseases. General recommendations on immunization --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011 Abstract Full text (in our servers)
  10. Pisacane A, Continisio P, Palma O, Cataldo S, De Michele F, Vairo U. Breastfeeding and risk for fever after immunization. Pediatrics. 2010 Abstract Full text (in our servers)
  11. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (in our servers)
  12. Hawkes JS, Makrides M, Roberton DM, Gibson RA. Responses to immunisation with Hib conjugate vaccine in Australian breastfed and formula-fed infants. J Paediatr Child Health. 2007 Sep;43(9):597-600. Abstract
  13. Silfverdal SA, Ekholm L, Bodin L. Breastfeeding enhances the antibody response to Hib and Pneumococcal serotype 6B and 14 after vaccination with conjugate vaccines. Vaccine. 2007 Feb 9;25(8):1497-502. Epub 2006 Oct 30. Abstract
  14. Schmidt JV, Kroger AT, Roy SL. Report from the CDC. Vaccines in women. J Womens Health (Larchmt). 2004 Abstract
  15. López-Alarcón M, Garza C, Habicht JP, Martínez L, Pegueros V, Villalpando S. Breastfeeding attenuates reductions in energy intake induced by a mild immunologic stimulus represented by DPTH immunization: possible roles of interleukin-1beta, tumor necrosis factor-alpha and leptin. J Nutr. 2002 Abstract Full text (in our servers)
  16. Pickering LK, Granoff DM, Erickson JR, Masor ML, Cordle CT, Schaller JP, Winship TR, Paule CL, Hilty MD. Modulation of the immune system by human milk and infant formula containing nucleotides. Pediatrics. 1998 Feb;101(2):242-9. Abstract
  17. Pabst HF, Spady DW, Pilarski LM, Carson MM, Beeler JA, Krezolek MP. Differential modulation of the immune response by breast- or formula-feeding of infants. Acta Paediatr. 1997 Abstract
  18. Scheifele D, Bjornson GJ, Guasparini R, Friesen B, Meekison W. Breastfeeding and antibody responses to routine vaccination in infants. Lancet. 1992 Dec 5;340(8832):1406. No abstract available. Abstract
  19. Pabst HF, Spady DW. Effect of breast-feeding on antibody response to conjugate vaccine. Lancet. 1990 Aug 4;336(8710):269-70. Abstract
  20. Hahn-Zoric M, Fulconis F, Minoli I, Moro G, Carlsson B, Böttiger M, Räihä N, Hanson LA. Antibody responses to parenteral and oral vaccines are impaired by conventional and low protein formulas as compared to breast-feeding. Acta Paediatr Scand. 1990 Abstract
  21. Insel RA, Amstey M, Pichichero ME. Postimmunization antibody to the Haemophilus influenzae type b capsule in breast milk. J Infect Dis. 1985 Aug;152(2):407-8. No abstract available. Abstract

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