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It is a derivative of nitrofuran with antiprotozoal and antibacterial activity.
Indicated in the treatment of giardiasis and cholera. In other types of gastroenteritis antibiotic treatment is not usually indicated. It is also used in the treatment of peptic ulcer caused by Helicobacter pylori.
Oral administration 4 times a day for 2 to 5 days or a maximum of 7 to 10 days in Giardia lamblia infestation.
Since the last update we have not found published data on its excretion in breastmilk.
Little is known of this drug’s pharmacokinetic data in humans.
There is controversy about its oral bioavailability. Although it is believed that it exerts its effect locally in the intestine without being absorbed (Kumar 1995, Valadez 1989), there are authors who have recorded 65% absorption (Calafatti 2001 -> White 1989).
Side effects are rare and mild, usually nausea/vomiting (Altamirano 1989). Although its properties as a monoamine oxidase inhibitor (MAOI) are known, no adverse neurological reactions due to the isolated use of this drug have been recorded (Karamanakos 2008, Bettinger 1968).
Its use is authorized in infants from the one month old (Induquímica 2018, RxList 2004, Drugs.com 1995).
Do not use if there is a history of glucose-6-phosphate dehydrogenase deficiency, in order to avoid risk of hemolysis (Induquímica 2018, RxList 2004, Drugs.com 1995).
Some authors discourage its use during breastfeeding (Mahadevan 2006). Other authors and the manufacturer only advise against its use in mothers with infants younger than one month (Induquímica 2018, Drugs.com 1995).
One mother told us in 2018 that after taking 4 doses of 100 mg of furazolidone along with famotidine, over 24 hours she noticed more drowsiness than usual in her 13-week-old breastfeeding daughter, returning to normal within 48 hours of stopping the medication.