Last update April 3, 2018

Framycetin Sulfate


Safe substance and/or breastfeeding is the best option.

An aminoglycoside antibiotic with similar characteristics and actions as neomycin.
Used topically at 1% in skin infections and 0.5% in ear and eye infections.
Given its practically zero intestinal absorption, it has been used orally for selective intestinal decontamination, preoperatively or in intensive care patients.

Since the last update we have not found published data on its excretion in breast milk.

he small dose and poor plasma absorption of most topical preparations (dermatological or otological) make it very unlikely that significant amounts will transfer into breastmilk, although following subconjunctival injection plasma levels of 5 micrograms/ml have been observed, similar to those obtained following intramuscular injection (Bron 1970).

The small dose and low plasma absorption of most topical preparations make it unlikely that a significant amount will transfer into breastmilk. In addition, its zero or very low oral bioavailability would make it difficult for it to transfer to infant plasma from ingested breast milk, except in premature infants and the immediate neonatal period when there may be greater intestinal permeability.


We do not have alternatives for Framycetin Sulfate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Framycetin Sulfate is also known as

Framycetin Sulfate in other languages or writings:


Main tradenames from several countries containing Framycetin Sulfate in its composition:


Variable Value Unit
Oral Bioavail. bajo - poor %
Molecular weight 615 daltons


  1. Soussan C, Gouraud A, Portolan G, Jean-Pastor MJ, Pecriaux C, Montastruc JL, Damase-Michel C, Lacroix I. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014 Abstract
  2. Bron AJ, Richards AB, Knight-Jones D, Easty DL, Ainslie D. Systemic absorption of Soframycin after subconjunctival injection. Br J Ophthalmol. 1970 Abstract Full text (link to original source)

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