Last update Dec. 24, 2024

Flurbiprofen

Compatible

Safe product and/or breastfeeding is the best option.

It is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and is used orally for musculoskeletal and joint disorders (ankylosing spondylitis, osteoarthritis, rheumatoid arthritis), sprains, postoperative pain, dysmenorrhea and migraine. Also in the form of lozenges for symptomatic relief of sore throat and in eye drops for ocular inflammatory disorders.

It is excreted in breast milk in clinically insignificant or undetectable amounts. (Smith 1989, Cox 1987)

No jaundice problems have been observed in newborns whose mothers took it. (Fu 2020)

Several medical societies and expert authors consider the use of this medication safe during breastfeeding. (Briggs 2015, Sachs 2013, Lee 1993, Goldsmith 1989, Needs 1985)


See below the information of these related products:

  • Maternal Rheumatoid arthritis (RA) (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Migraine (Safe product and/or breastfeeding is the best option.)

Alternatives

We do not have alternatives for Flurbiprofen since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Flurbiprofen in other languages or writings:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 244 daltons
Protein Binding 99 %
VD 0.2 l/Kg
Tmax 0.5 - 4 hours
4.7 - 5.7 hours
M/P ratio 0.008 - 0.01 -
Theoretical Dose 0.01 - 0.002 mg/Kg/d
Relative Dose 0.1 - 0.5 %

References

  1. Fu SC, Wang CY, Lin CK. Do postpartum nonsteroidal antiinflammatory drugs (NSAIDs) affect neonatal hyperbilirubinaemia? Taiwan J Obstet Gynecol. 2020 Nov;59(6):891-894. Abstract Full text (link to original source)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  4. Davies NM. Clinical pharmacokinetics of flurbiprofen and its enantiomers. Clin Pharmacokinet. 1995 Abstract
  5. Lee JJ, Rubin AP. Breast feeding and anaesthesia. Anaesthesia. 1993 Jul;48(7):616-25. Review. Abstract Full text (link to original source) Full text (in our servers)
  6. Smith IJ, Hinson JL, Johnson VA, Brown RD, Cook SM, Whitt RT, Wilson JT. Flurbiprofen in post-partum women: plasma and breast milk disposition. J Clin Pharmacol. 1989 Abstract
  7. Goldsmith DP. Neonatal rheumatic disorders. View of the pediatrician. Rheum Dis Clin North Am. 1989 Abstract
  8. Cox SR, Forbes KK. Excretion of flurbiprofen into breast milk. Pharmacotherapy. 1987 Abstract
  9. Needs CJ, Brooks PM. Antirheumatic medication during lactation. Br J Rheumatol. 1985 Abstract

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