Last update Feb. 13, 2022

Fluocortolone

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Glucocorticoid of moderate potency used topically in skin problems. Can also be administered orally.

Although at the date of the last revision there are no published data in relation to breastfeeding, the low absorption through the skin makes it unlikely that a significant amount will pass into breast milk. (Butler 2014, Westermann 2012)

In addition, systemic glucocorticoids, at usual doses, do not contraindicate breastfeeding (Butler 2014, WHO 2002, AAP 2001). Corticosteroids, in the form of cortisol, are a natural component of colostrum and breast milk. (Kulsky 1981)

If used, do not apply on the breast or large areas or for prolonged periods to avoid systemic absorption.

If they are required to treat eczema or dermatosis of the nipple, it is advisable to choose the less powerful corticosteroid, apply it just after finishing the intake so that it has been reabsorbed before the next one; if necessary remove remains with gauze and do not use for more than a week.

It is recommended to avoid using on the nipple creams, gels and other products intended for use on skin that may contain paraffin (mineral oil) in order to keep from absorption the infant. (Concin 2008, Noti 2003)

The American Academy of Pediatrics considers systemic corticosteroids to be compatible with lactation, recommending prednisone or prednisolone because they are known to be poorly excreted in breast milk. (AAP 2001)
WHO 2002 essential medicines list: Prednisolone is compatible with breastfeeding. (WHO 2002)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Fluocortolone is also known as


Fluocortolone in other languages or writings:

Tradenames

Main tradenames from several countries containing Fluocortolone in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. oral: 80; derm.: poor. baja %
Molecular weight 377 daltons
Protein Binding 83 - 95 %
VD 1.03 l/Kg
pKa 13.84 -
Tmax 1.4 - 2.1 hours
1.25 - 1.76 hours

References

  1. AEMPS. Fluocortolona. Ficha técnica. 2018 Full text (in our servers)
  2. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  3. Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012 Feb;39(2):168-71. Abstract
  4. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  5. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  7. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  8. Legler UF. Pharmacokinetics of fluocortolone in man. Eur J Clin Pharmacol. 1986;30(5):615-7. Abstract
  9. Täuber U, Haack D, Nieuweboer B, Kloss G, Vecsei P, Wendt H. The pharmacokinetics of fluocortolone and prednisolone after intravenous and oral administration. Int J Clin Pharmacol Ther Toxicol. 1984 Jan;22(1):48-55. Abstract
  10. Kulski JK, Hartmann PE. Changes in the concentration of cortisol in milk during different stages of human lactation. Aust J Exp Biol Med Sci. 1981 Dec;59(Pt 6):769-78. Abstract

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