Last update March 11, 2022
Likely Compatibility
We do not have alternatives for Flumazenil, Flumazepil.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Flumazenil, Flumazepil in other languages or writings:
Flumazenil, Flumazepil belongs to this group or family:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 16 - 20 | % |
Molecular weight | 303 | daltons |
Protein Binding | 50 | % |
VD | 0.5 - 1.1 | l/Kg |
pKa | 1.7 | - |
Tmax | 0.1 - 0.17 | hours |
T½ | 0.8 | hours |
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e-lactancia is a resource recommended by La Liga de la Leche, España of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Benzodiazepine receptor antagonist that blocks the neurological effects of benzodiazepines. Used in anesthesia to reverse sedation and in benzodiazepine overdose. intravenous administration.
At the date of the last update we did not find any published data on its excretion in breast milk.
Its large volume of distribution would make excretion in breast milk difficult.
Its very low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.
Very well tolerated drug with few side effects and few serious.
Authorized use in Neonatology and Pediatrics. (Kreshak 2012, Zaw 2001, Dixon 1998, Richard 1991)
Several medical societies, experts and expert consensus consider the use of this medication to be probably compatible during breastfeeding. (Hale, Briggs 2015, Mahadevan 2006)