Last update Aug. 20, 2022
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Felodipine in other languages or writings:
Felodipine belongs to this group or family:
Main tradenames from several countries containing Felodipine in its composition:
|Oral Bioavail.||10 - 25||%|
|Tmax||3 - 5||hours|
|T½||11 - 25||hours|
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
It is a dihydropyridine-type calcium channel blocker. It is used in the treatment of hypertension and angina pectoris. Oral administration once daily.
At latest update no published data were found on excretion into breast milk.
Its high percentage of plasmatic protein binding and very wide volume of distribution makes it highly unlikely a passage into breast milk.
Its very low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.
Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.
It has been described an increased Prolactin plasma level and gynecomastia after using felodipine and cyclosporine. (Pan 1997)
Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.