Last update Nov. 9, 2024
Limited compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Variable | Value | Unit |
---|---|---|
Oral Bioavail. | > 90 | % |
Molecular weight | 238 | daltons |
Protein Binding | 20 - 36 | % |
VD | 0. 76 ± 0.08 | l/Kg |
pKa | 14.98 | - |
Tmax | 1 - 6 | hours |
T½ | 16 - 23 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Felbamate is a carbamate structurally related to meprobamate. It is used in the treatment of epilepsy (refractory partial seizures with or without secondary generalization and in children with Lennox-Gastaut syndrome. Due to its toxicity, it should only be used in severe cases that do not respond to other drugs. Oral administration in 3 to 4 daily doses.
At the date of the last update we found no published data on its excretion in breast milk.
Its pharmacokinetic data (low molecular weight, low binding to plasma proteins and prolonged half-life) make it likely to pass into breast milk in quantities that could be significant.
Due to its possible serious side effects: aplastic anemia, hepatic failure, Stevens-Johnson syndrome… (Jacob 2016), this drug is not recommended during lactation, preferring other known safer drugs. (Veiby 2015, Bar-Oz 2000, Hägg 2000)