Last update Nov. 9, 2024

Felbamate

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Felbamate is a carbamate structurally related to meprobamate. It is used in the treatment of epilepsy (refractory partial seizures with or without secondary generalization and in children with Lennox-Gastaut syndrome. Due to its toxicity, it should only be used in severe cases that do not respond to other drugs. Oral administration in 3 to 4 daily doses.

At the date of the last update we found no published data on its excretion in breast milk.

Its pharmacokinetic data (low molecular weight, low binding to plasma proteins and prolonged half-life) make it likely to pass into breast milk in quantities that could be significant.

Due to its possible serious side effects: aplastic anemia, hepatic failure, Stevens-Johnson syndrome… (Jacob 2016), this drug is not recommended during lactation, preferring other known safer drugs. (Veiby 2015, Bar-Oz 2000, Hägg 2000)

Alternatives

  • Lamotrigine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Topiramate (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Felbamate in other languages or writings:

Group

Felbamate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Felbamate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. > 90 %
Molecular weight 238 daltons
Protein Binding 20 - 36 %
VD 0. 76 ± 0.08 l/Kg
pKa 14.98 -
Tmax 1 - 6 hours
16 - 23 hours

References

  1. Jacob S, Nair AB. An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs. Drugs R D. 2016 Abstract Full text (link to original source) Full text (in our servers)
  2. Veiby G, Bjørk M, Engelsen BA, Gilhus NE. Epilepsy and recommendations for breastfeeding. Seizure. 2015 May;28:57-65. Abstract Full text (link to original source)
  3. Hägg S, Spigset O. Anticonvulsant use during lactation. Drug Saf. 2000 Jun;22(6):425-40. Review. Abstract
  4. Bar-Oz B, Nulman I, Koren G, Ito S. Anticonvulsants and breast feeding: a critical review. Paediatr Drugs. 2000 Mar-Apr;2(2):113-26. Review. Abstract

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