Last update June 10, 2018



Safe substance and/or breastfeeding is the best option.

A bactericidal and fungicidal antiseptic.
Used topically in mild mucus infections (vaginal, 0.1% mouthwash for oral hygiene).

Since the last update we have not found published data on its excretion in breast milk.

The small dose and low plasma absorption of most topical preparations make it unlikely that significant amounts will be transferred into breastmilk, as stated in information for hexetidine (McNeil Products Ltd 2017).

A case of contact dermatitis has been documented following its use (Merk 1982), so contact should be avoided with mucous membranes or the baby’s skin.

As an oral antiseptic it is much less effective than chlorhexidine (Afennich 2011).


  • Chlorhexidine (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Εξετιδίνη is Hexetidine in Greek.

Is written in other languages:


Main tradenames from several countries containing Εξετιδίνη in its composition:


Variable Value Unit
Molecular weight 340 daltons


  1. McNeil Products Ltd. Oraldene (Hexetidine). Drug Summary. 2017 Full text (in our servers)
  2. Afennich F, Slot DE, Hossainian N, Van der Weijden GA. The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review. Int J Dent Hyg. 2011 Abstract
  3. Parke Davis. Hexetidina. Ficha técnica. 2000 Full text (in our servers)
  4. Merk H, Ebert L, Goerz G. Allergic contact dermatitis due to the fungicide hexetidine. Contact Dermatitis. 1982 Abstract

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