Last update Jan. 9, 2023
Very High Risk
We do not have alternatives for Exemestane.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Exemestane in other languages or writings:
Exemestane belongs to these groups or families:
Main tradenames from several countries containing Exemestane in its composition:
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
It is a selective aromatase inhibitor (estrogen synthetase), which inhibits the secretion of estrogen.
Indicated in the treatment of breast cancer in postmenopause. Oral administration once a day for several years.
Since the last update we have not found published data on its excretion in breastmilk.
Its high plasmatic protein binding and very wide volume of distribution make it difficult to pass into breast milk.
Pharmacokinetics show that after 3 elimination half-lives (T½) 87.5% of the drug is eliminated from the body; after 4 T½ it is 94%, after 5 T½, 96.9%, after 6 T½, 98.4% and after 7 T½ it is 99%. From 7 T½ the plasma concentrations of the drug in the body are negligible. In general, a period of at least five half-lives can be considered a safe waiting period before breastfeeding again (Anderson 2016).
According to this data, the interruption of breastfeeding would be for a period of between 5 days (5 T½) to 7 days (7 T½) after the administration of the last dose.
Its administration every 24 hours over many years make it impossible to continue breastfeeding.
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