Last update March 26, 2022
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
Ethinylestradiol + Etonogestrel is also known as
Ethinylestradiol + Etonogestrel in other languages or writings:
Ethinylestradiol + Etonogestrel belongs to this group or family:
Main tradenames from several countries containing Ethinylestradiol + Etonogestrel in its composition:
|Oral Bioavail.||40 - 60 /||%|
|Molecular weight||299 / 325||daltons|
|Protein Binding||99 / 96 - 99||%|
|VD||5 / 3.1||l/Kg|
|Tmax||2 / 200||hours|
|T½||18 / 25||hours|
|M/P ratio||0.3 / 0.5||-|
|Theoretical Dose||0.000045 / 0.00003||mg/Kg/d|
|Relative Dose||0 / 2.2||%|
Write us at email@example.com
e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Estrogen (ethinyl estradiol) and progestogen (etonogestrel) combined hormonal contraceptive (CHC) in the form of a vaginal ring (3 of every 4 weeks).
Hormonal contraceptives, both combined (CHC) and progestogen-only, do not alter the composition of milk, neither in minerals (Mg, Fe, Cu, Ca, P) nor in fats, lactose, proteins or calories. (Urzica 2013, Dórea 2000, 1999 y 1998, Costa 1992)
No short-term or long-term clinical, physical or psychomotor developmental problems have been observed in infants whose mothers were taking a CHC (Lopez 2015, Nilsson 1986), except for a few cases published years ago of transient gynecomastia. (Madhavapeddi 1985, Nilsson 1978, Marriq 1974, Curtis 1964)
No study has found negative effects on breast milk production or infant weight gain when CHC are started after the first 2, or better 6, weeks postpartum. (Tepper 2015, Bahamondes 2013, Espey 2012)
During lactation progestin-only contraceptives are preferable to those combined with estrogen and, in this case, those with a lower dose of estrogen. (CDC 2016, 2013 y 2010, WHO/OMS 2015, Altshuler 2015, Berens 2015, CLM 2012)
If a CHC is used during lactation, it is advisable not to start it before a month and a half after delivery and monitor milk production through the growth of the infant. (Moretti 2000)
For the first 4-6 weeks postpartum, non-hormonal methods are the first choice, followed by IUDs and progestogen implants. (Berens 2015, Mwalwanda 2013, Rowe 2013, CLM 2012)
The American Academy of Pediatrics states that CHC are usually compatible with breastfeeding. (AAP 2001)
ETHINYLESTRADIOL is a synthetic estrogen that has a similar action as estradiol.
Its pharmacokinetic data (high percentage of protein binding and very wide volume of distribution) explain the negligible or null passage into breast milk observed. (Betrabet 1986, Nilsson 1978)
Estrogens, alone or associated with progestogens, have been used in the treatment of excess milk production(Johnson 2020) and to suppress lactation (Piya 2004, Balmer 1971), although with very little success. (Kaern 1967)
There is low quality evidence that estrogen-containing pills may decrease milk production or the duration of breastfeeding, especially if given during the first few weeks postpartum and with a daily dose equal to or greater than 30 micrograms (0,03 mg) diarios.(WHO 2002, AAP 2001, WHO 1988, Nilsson 1986, Tankeyoon 1984, Díaz 1983, Peralta 1983, Croxatto 1983, Guiloff 1974, Kaern 1967)
ETONOGESTREL i a progestin, active metabolite of desogestrel.
It is excreted in breast milk in negligible amount (Reinprayoon 2000) and no problems were observed in infants whose mothers used this medication. (Carmo 2017, Bahamondes 2013, Brito 2009, Taneepanichskul 2006)
See below the information of these related products: