Last update Feb. 12, 2019

Epinastine Hydrochloride

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

A second generation antihistamine that does not cross the blood-brain barrier, with no sedative or antimuscarinic effects (AEMPS 2015).
Oral administration or as eye drops.

Since the last update we have not found published data on its excretion in breastmilk.

Second generation antihistamines are considered safe during breastfeeding due to their lack of sedative effect as they do not cross the blood-brain barrier. When taken orally, it is recommended to use the lowest effective dose.

Until there is more information about this drug taken orally in relation to breastfeeding, safer known alternatives may be preferable, especially during the first month and in mothers of premature infants.

The small dose and poor plasma absorption of most topical ophthalmic preparations make it unlikely that significant amounts will transfer into breastmilk.
Ophthalmic epinastine reaches insignificant plasma concentration: 0.042 ng/ml (Allergan 2018 and 2012).
In ophthalmic administration, absorption can be minimized by pressing the tear duct (inner canthus of the eye) for 1 minute with a finger.

Its ophthalmic use is compatible with breastfeeding.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Epinastine Hydrochloride in other languages or writings:


Epinastine Hydrochloride belongs to these groups or families:


Main tradenames from several countries containing Epinastine Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 40 %
Molecular weight 286 daltons
Protein Binding 64 %
VD 5.96 l/Kg
pKa 8.77 -
Tmax 2 hours
8 - 12 hours


  1. Allergan. Epinastina. Ficha técnica. 2018 Full text (in our servers)
  2. Allergan. Epinastine. Drug Summary. 2012 Full text (in our servers)
  3. Pradhan S, Abhishek K, Mah F. Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects. Expert Opin Drug Metab Toxicol. 2009 Abstract

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