Last update July 14, 2023

Entecavir

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Entecavir is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. It is used for the treatment of chronic hepatitis B. Oral administration once daily.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its pharmacokinetic data do not allow predicting the amount of its possible excretion in breast milk. Although the high volume of distribution would prevent it, its low binding to plasma proteins and long elimination half-life would favor its excretion in breast milk.

Pending further published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in case of prematurity.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Entecavir in other languages or writings:

Group

Entecavir belongs to this group or family:

Tradenames

Main tradenames from several countries containing Entecavir in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 295 daltons
Protein Binding 13 %
VD > 0.7 l/Kg
pKa 12 -
Tmax 0.5 - 1.5 hours
128 - 149 hours

References

  1. AEMPS. Entecavir. Ficha técnica. 2020 Full text (in our servers)
  2. Bristol-M-S. Entecavir. Drug Summary. 2020 Full text (in our servers)

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